there are other posts about users who need to do a 'netsh interface ... disable' before things start working again; I don't know what the exact problem is, and I don't see it myself on my Win7 box, but I'll keep a tap on it.
By the way, is it still true that tun mode does not work for Windows (from the documentation) or does version 2.2 support tun mode on Windows?
OpenVPN 2.0 already supported 'tun' mode, it's just that the device driver is always called 'tap-win32' ; to use 'tun' mode, simple use
dev tun
dev-node OpenVPN-UDP