Me too, for many years.
Actually. I had this in the first tunnel
link-mtu 1464
mssfix 1464
(1500 - 8 PPPoE - 20 hdr - 8 udp)
and this in the next-inner tunnels:
mssfix 1375
tun-mtu 1280
But with IP6 the math for outer tunnel is 1500 - 20 gif - 40 hdr - 8 udp, and the next-inner will then also get smaller, and hit the minimum requirement of 1280. So it was not an option anymore.