Hello ioannis,
You need a script that loads your Let's Encrypt certificates into the Access Server configuration database. These commands should serve as an example:
/usr/local/openvpn_as/scripts/sacli --key "cs.priv_key" --value_file "/etc/letsencrypt/live/blabla.com/privkey.pem" ConfigPut
/usr/local/openvpn_as/scripts/sacli --key "cs.cert" --value_file "/etc/letsencrypt/live/blabla.com/cert.pem" ConfigPut
/usr/local/openvpn_as/scripts/sacli --key "cs.ca_bundle" --value_file "/etc/letsencrypt/live/blabla.com/chain.pem" ConfigPut
/usr/local/openvpn_as/scripts/sacli start
Note that if the certificate is loaded but it doesn't show as trusted, that you need to figure out what you're missing to making that trust complete successfully.
Kind regards,
Johan