Now that you have mentioned it I do see the following error in the logs
2019-12-02T18:24:40+0000 [stdout#info] u"DBBase._rollback: exception in session.rollback(): (MySQLdb._exceptions.OperationalError) (2006, 'MySQL server has gone away')\n(Background on this error at:
http://sqlalche.me/e/e3q8): db/dbase:85,orm/session:990,orm/session:563,orm/session:523,engine/base:1705,engine/base:1743,engine/base:741,engine/base:1466,util/compat:383,engine/base:739,mysql/base:2227 (sqlalchemy.exc.OperationalError)"
We are running a cluster and once we hit this error on one node, other nodes also run into a problem with an invalid transaction
openvpnas.log.300:2019-11-25T16:23:42+0000 [stdout#info] Reason: <Fault 9000: "sqlalchemy.exc.StatementError: (sqlalchemy.exc.InvalidRequestError) Can't reconnect until invalid transaction is rolled back\n[SQL: SELECT config.profile_id AS config_profile_id, config.name AS config_name, config.value AS config_value \nFROM config INNER JOIN profile ON profile.id = config.profile_id \nWHERE config.name IN (%s) AND profile.name = %s]\n[parameters: [{}]]">