Random disconnects

[turre]

RPI2 Raspian Server via Fitzbox 6360 (Kabel Deutschland)

[server]
port 1yy4
proto udp
dev tun
ca ./easy-rsa2/keys/ca.crt
cert ./easy-rsa2/keys/server.crt
key ./easy-rsa2/keys/server.key
dh ./easy-rsa2/keys/dh1024.pem
server 10.xx.0.0 255.255.255.0
ifconfig-pool-persist ipp.txt
keepalive 10 120
comp-lzo
persist-key
persist-tun
status openvpn-status.log
log-append openvpn.log
verb 3

[client]
client
dev tun
proto udp
status openvpn-status.log
log-append /etc/openvpn/openvpn.log
remote yyyyyyyyyy.net 12345
resolv-retry infinite
nobind
persist-key
persist-tun
ca /etc/openvpn/ca.crt
cert /etc/openvpn/client1.crt
key /etc/openvpn/client1.key
ns-cert-type server
comp-lzo
verb 3

[LOG]
client1/89.15.xxx.yyy:54120 SENT CONTROL [client1]: 'PUSH_REPLY,route 10.xx.0.1,topology net30,ping 10,ping-restart 120,ifconfig 10.xx.0.6 10.xx.0.5' (status=1)
read UDPv4 [ECONNREFUSED]: Connection refused (code=111)
read UDPv4 [EHOSTUNREACH]: No route to host (code=113)
89.15.xxx.yyy:51028 TLS Error: TLS key negotiation failed to occur within 60 seconds (check your network connectivity)
89.15.xxx.yyy:51028 TLS Error: TLS handshake failed
89.15.xxx.yyy:51028 SIGUSR1[soft,tls-error] received, client-instance restarting

These Interruptions occur every day 3 to 4 times
Please could somebody check above configurations considering inconsistencies.
Thank you.